(Tilton Group)
3D (Bio)printed functionalized scaffolds for minimally invasive tissue regeneration
To address some of the current challenges with minimally invasive treatment of degenrative musculoskeletal diseases, our lab develops 3D (bio)printed injectable functionalized scaffolds. In this project, we explore diverse biomaterials, 3D biofabrication methods, and biochemical functionalization approaches for targeted minimally invasive tissue regeneration.
Senescence-associated degenerative mechanisms in musculoskeletal tissue
Aging is a significant risk factor for chronic diseases, including bone loss. This project explores the impact of age-related accumulation of senescent cells and their secreted phenotypes on MSK disorders, such as bone loss. Specifically, we investigate the local and systemic effects of senescence-associated secretory phenotypes on osteocyte mechano-responsiveness and transduction. The outcomes of such mechanistic study facilitate the development of new strategies to mitigate and/or treat age-related bone loss.
Age-related intervertebral disc (IVD) pathologies and restoration
Through mapping micromechanical profiles to biomolecular compositions, we aim to uncover complex degenerative mechanisms in IVD. These insights helps us and others to develop innovative strategies for addressing age-related IVD pathologies.
