Skeletal Aging Mechanobiology & Repair
Across skeletal tissues, cells and the extracellular matrix continuously tune one another: cells sense mechanical inputs, convert them into biochemical signals, and reshape the matrix that sets the next round of sensing. We study how this loop shifts with age and accumulation of senescent cells. Using advanced 3D biomanufacturing, mechanobiology test platforms, and molecular assays, we translate mechanisms into minimally invasive strategies to improve repair in the aging skeleton.